The linker is the spacer part between a cargo molecule, consisting of radionuclide and chelator, and the targeting molecule, constructing a covalent bond between them. Linker, as an important part of RDC (Radionuclide Drug Conjugate), has a great effect on the bioactivity of RDC.

Since the structure and design of the linker are critical to the success of RDC, Rdcthera, focused on linker development for decades, offers professional linker design and high-quality synthesis for customers to ensure the later RDC development.

Overview of Linker Synthesis Service in RDC

RDC is composed of four parts, including radionuclide, chelator, linker, and targeting biomolecule. After the connection between radioactive particle and chelator, this complex needed to binding to the targeting molecule by a linker to avoid interferences between bioactive groups in RDC. The linker in the RDC, also named as PKM (Pharmacokinetic Modifying) linker, has a significant effect on radiotracer excretion kinetics of RDC to improve the T/B (target-to-background) ratios of the radiopharmaceutical.

Examples of Linkers in RDC

Several linkers have been successfully designed including cationic, anionic, neutral, and metabolically cleavable linkers. Depending on the specific needs, the relatively best linker can be chosen. The following linkers shown in the chart are part of our linker library. With years of linker design service, our professional team can help you find the most suitable linker for your RDC.

Fig.1 Linkers for modification of pharmacokinetics of radiopharmaceuticals.
(Liu S., Adv Drug Deliv Rev., 2008)